Toxicol Res.
2012 Mar;28(1):51-56.
The Safety Evaluation of a Potent Angiogenic Activator, Synthetic Peptide (SFKLRY-NH2) for the Skin Application
- Affiliations
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- 1Department of Dermatology, Chung-Ang University College of Medicine, Seoul 156-755, Korea. beomjoon@unitel.co.kr
- 2NOVACELL Technology, Pohang 790-784, Korea.
- 3Functional Food & Nutrition Division, National Academy of Agricultural Science, Rural Development Administration, 160 Nokjiro, Gwonseon-gu, Suwon, Gyeonggi-do 441-853, Korea. soomuk@korea.kr
Abstract
- A novel synthetic hexapeptide (SFKLRY-NH2) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). This study was carried out to investigate the irritation of the SFKLRY-NH2 on the skin. The tests were performed on the basis of Korea Food and Drug Administration (KFDA) guidelines. In results, cell toxicity is not appeared for SFKLRY-NH2 in HaCaT cells and B16F10 cells. SFKLRY-NH2 induced no skin irritation at low concentration (10 microM), mild irritation at high concentration (10mM). We consider that this result is helpful for saying about the safety of SFKLRY-NH2 in clinical use.
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