Electrolyte Blood Press.
2005 Nov;3(2):91-96.
Altered Regulation of Renal Aquaporins and Sodium Transporters in Experimental Chronic Renal Failure
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- 1Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Korea. thkwon@knu.ac.kr
Abstract
- Chronic renal failure, which has an increased single nephron glomerular filtration rate in remnant kidney, is known to cause characteristic structural alterations in renal tubule epithelia in association with impaired urinary concentration and deranged urinary sodium excretion. This mini-review will deal with the changes in the renal expression of aquaporins (AQPs) and sodium transporters for elucidating the underlying cellular and molecular mechanisms for the urinary abnormalities of decreased urinary concentration and increased urinary sodium excretion.
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