J Korean Soc Hypertens.  2013 Mar;19(1):17-22. 10.5646/jksh.2013.19.1.17.

Renal Sodium Transporters and Water Channels

Affiliations
  • 1Division of Nephrology, Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea. hyekim@chungbuk.ac.kr

Abstract

Hypertension is closely related to salt and water retention. The kidney plays an important role in the blood pressure regulation primarily to modulating tubular sodium and water reabsorption. The regulation of the salt and water balance depends upon an array of solute and water channels in the renal tubules. An altered regulation of sodium and water channels in the kidney may be related to various pathological conditions associated with altered salt and water retention. This review will discuss renal handling of sodium and water, with particular emphasis on aquaporins and renal sodium transporters and channels.

Keyword

Aquaporins; Sodium; Membrane transport proteins; Kidney

MeSH Terms

Aquaporins
Blood Pressure
Handling (Psychology)
Hypertension
Kidney
Membrane Transport Proteins
Retention (Psychology)
Sodium
Water
Aquaporins
Membrane Transport Proteins
Sodium
Water
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