Nucl Med Mol Imaging.
2010 Apr;44(1):25-32.
Recent Trends in the Nucleophilic [18F]-radiolabeling Method with No-carrier-added [18F]fluoride
- Affiliations
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- 1Department of Nuclear Medicine, Cyclotron Research Center, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-712, Korea.
- 2Department of Nuclear Medicine, Cyclotron Research Center, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-712, Korea. kimdw@chonbuk.ac.kr
Abstract
- Noninvasive imaging in living subjects with positron emission tomography (PET) provides early detection of diseases in humans. For this application, it is necessary to prepare specific molecular imaging probes labeled with positron-emitting radioisotopes such as fluorine-18 for obtaining high-quality PET imaging. In this review, we describe recent trends in the F-18 radiolabeling method for the introduction of no-carrier-added fluorine-18, which was obtained from an 18O(p,n)18F reaction, into a specific molecular site, which in turn is intended to serve as an imaging agent for PET study. These labeling protocols are based on ionic liquid media 18F radiofluorination in the presence of some water, enzymatic 18F fluorination using fluorinase in water solution, non-polar protic alcohol media 18F radiofluorination and its mechanism, and nucleophilic 18F fluorination of an aromatic iodonium salt precursor.
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