Clin Pediatr Hematol Oncol.  2013 Apr;20(1):62-65.

Pneumococcal Sepsis 8 Years after Splenectomy for Chronic Immune Thrombocytopenia: A Case of Vaccinated 12-year-old Patient

Affiliations
  • 1Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. cj@yuhs.ac

Abstract

Splenectomy is a safe and effective procedure in the refractory or chronic immune thrombocytopenia (ITP) patients. Overwhelming post-splenectomy infection (OPSI) is rare but fatal. The lifetime risk of post-splenectomy patients to develop an OPSI with encapsulated bacteria (Streptococcus pneumoniae, Haemophilus influenzae or Neisseria meningitidis) is about 1-5% and the mortality is reported more than 50% in 48 hours. Though vaccination against encapsulated bacteria cannot prevent all infection, vaccination is essential for the patients. We report a case of OPSI in a 12-year-old post-splenectomy boy who was vaccinated pneumococcal polysaccharide 7-valent against pneumococcus (Streptococcus pneumoniae) 2 months before splenectomy.

Keyword

Immune thrombocytopenia; Splenectomy; Pneumococcal vaccine; Sepsis

MeSH Terms

Bacteria
Haemophilus influenzae
Humans
Neisseria
Pneumonia
Sepsis
Splenectomy
Streptococcus pneumoniae
Thrombocytopenia
Vaccination
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