Clin Pediatr Hematol Oncol.  2010 Apr;17(1):1-8.

Management of Iron Deficiency Anemia Associated with Dysfunctional Uterine Bleeding in the Adolescent Females

• Lee SS
• Hwang ST
• Nam KL
• Tchah H
• Lee JS
• Jeon IS

Abstract

PURPOSE
To investigate hematologic features and the appropriate management in Korean adolescent females with dysfunctional uterine bleeding (DUB) and iron deficiency anemia (IDA) we performed this study.
METHODS
We investigated retrospectively the initial complete blood count (CBC) profiles and the changes of the hemoglobin levels after iron only therapy or iron/hormone combination therapy in 23 adolescent girls (a group of 15 patients treated with oral iron only and another group of 8 patients treated with oral iron/hormone) with DUB and IDA.
RESULTS
A statistically significant correlation was observed between the increase of hemoglobin level and treatments in both groups. The increase of hemoglobin levels in group treated with iron only were inconsecutive in comparison with the consecutive increase of hemoglobin level in group treated with iron/hormone combination therapy during the subsequent six month follow-up. On the comparison of increase of hemoglobin level in two groups, the differences were statistically insignificant at 14, 30, 60 days after treatment but statistically significant at 90, 120, 150 days.
CONCLUSION
Iron/hormone combination therapy was more effective than iron only for consecutive increase of hemoglobin level in Korean adolescent females with DUB and IDA.

Keyword

Adolescent; Dysfunctional uterine bleeding; Iron deficiency anemia; Oral iron supplement; Hormone therapy

MeSH Terms

Adolescent
Anemia, Iron-Deficiency
Blood Cell Count
Female
Follow-Up Studies
Hemoglobins
Humans
Iron
Metrorrhagia
Retrospective Studies
Hemoglobins
Iron