Allergy.  1994 Sep;14(3):318-322.

Reactive airway dysfunction syndrome(RADS) following single exposure to irritant gases including isocyanate

• Park HS

Abstract

Reactive airway dysfunction syndrome (RADS) has been defined as a development of permanant asthmatic symptoms after a single massive exposure to an irritant, such as gas, vapor, aerosol, fume or smoke, usually as a result of an accident. We are reporting a case of RADS after the single exposure to irritant gas including isocyanate. He had worked as a plumber for five years. He denined that he had never fe}t respiratory symptoms before the accident. Several hours after the exposure, he had begun to feel shortness of breath and admitted at a hospital for one month, Inspire he stopped working and continued to take anti-asthmatic medications for two and half years, he had suffered from frequent asthmatic attacks Allergy skin prick test revealed positive responses to Dermatophagoides farinae(D.farinae 4x3/ 26x21 (mm)), and ermatophagoides pteronyssinus (5x4/32x26 (mm)). Total IgE level by PRIST was 1780 IU/m and IgE-RAST revealed class 2 response to d2, class 1 response to dl and negative results to isocyanate-human serum albumin(HSA) coniugates. Methacholine bronchial challenge test revealed a positive response at 2.5 mg/micor liter. TDI-bronchoprovocation test showed a dual asthmatic response and also D.farinae-bronchoprovecation test showed a dual asthmatic response. These results suggest that RADS might occur after a single massive exposure of irritant gases including isocyanate in a patient sensitized to an inhalalant allergen.

MeSH Terms

Bronchial Provocation Tests
Dyspnea
Gases*
Humans
Hypersensitivity
Immunoglobulin E
Methacholine Chloride
Pyroglyphidae
Skin
Smoke
Gases
Immunoglobulin E
Methacholine Chloride
Smoke