Clin Exp Reprod Med.  2011 Jun;38(2):103-108. 10.5653/cerm.2011.38.2.103.

Adverse pregnancy outcomes with assisted reproductive technology in non-obese women with polycystic ovary syndrome: a case-control study

• Han AR
• Kim HO
• Cha SW
• Park CW
• Kim JY
• Yang KM
• Song IO
• Koong MK
• Kang IS

• KMID: 2045703
• DOI: http://doi.org/10.5653/cerm.2011.38.2.103

Abstract

OBJECTIVE
To investigate adverse pregnancy outcomes in non-obese women with polycystic ovary syndrome (PCOS) compared with obese-PCOS and control groups.
METHODS
Women with PCOS who underwent assisted reproductive technology (ART) from August, 2003 to December, 2007, were considered. A total of 336 women with PCOS were included in the study group and 1,003 infertile women who had tubal factor as an indication for ART were collected as controls. They were divided into four groups: a non-obese PCOS group, obese-PCOS group, non-obese tubal factor group, and obese tubal factor group, with obesity defined by a body mass index over 25 kg/m2, and reviewed focusing on the basal characteristics, ART outcomes, and adverse pregnancy outcomes.
RESULTS
There was no difference among the groups' the clinical pregnancy rate or live birth rate. Regarding adverse pregnancy outcomes, the miscarriage rate, multiple pregnancy rate, and prevalence of preterm delivery and pregnancy induced hypertension were not different among the four groups. The incidence of small for gestational age infant was higher in the PCOS groups than the tubal factor groups (p<0.02). On the other hand, the morbidity of gestational diabetes mellitus (GDM) was not high in the non-obese PCOS group but was in the obese groups. And in the obese PCOS group, the newborns were heavier than in the other groups (p<0.02).
CONCLUSION
Non-obese PCOS presents many differences compared with obese PCOS, not only in the IVF-parameters but also in the morbidity of adverse pregnancy outcomes, especially in GDM and fetal macrosomia.

Keyword

Pregnancy Outcome; Polycystic Ovary Syndrome; Non-obese; Reproductive Techniques, Assisted; Diabetes, Gestational; Fetal Macrosomia; Human

MeSH Terms

Abortion, Spontaneous
Body Mass Index
Case-Control Studies
Diabetes, Gestational
Female
Fetal Macrosomia
Gestational Age
Hand
Humans
Hypertension, Pregnancy-Induced
Incidence
Infant
Infant, Newborn
Live Birth
Obesity
Ovary
Polycystic Ovary Syndrome
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Pregnancy, Multiple
Prevalence
Reproductive Techniques, Assisted