J Korean Assoc Maxillofac Plast Reconstr Surg.  2005 May;27(3):218-225.

Effect of alginate on early bone healing after implantation of particulate dentin and plaster of paris mixture

Affiliations
  • 1Oral Biology Research Institute, College of Dentistry, Chosun University, Gwangju, Korea.
  • 2Department of Pathology, Medical Research Institute, College of Medicine, Chosun University, Korea.
  • 3College of Dentistry, Medical Research Institute, College of Medicine, Chosun University, Korea. sgakim@chosun.ac.kr

Abstract

In this study, we expected that alginate would act as an antioxidant, owing to its antimicrobial and anti-parasitic effects and to clinical results in arthritic patients, and would thereby reduce the number of cytotoxic free radicals and the inflammatory reaction in response to grafting with a particulate dentin and plaster of Paris mixture, resulting in effective bone healing. In this study, the differences within groups at 4 and 8 weeks were not significant (p > 0.05), nor were the differences between the two experimental groups at 4 and 8 weeks. In comparison with the control group, however, both experimental groups showed superior new bone formation. Although the difference between the two experimental groups was not statistically significant, a tendency for superior new bone formation was detected with the combination of particulate dentin, plaster of Paris, and alginate. Furthermore, more fusion of woven bone and bony trabeculae formation occurred in this group, suggesting that oligosaccharides play a role in the formation and maturation of new bone. In conclusion, the treatment of bone defects by grafting with a mixture of particulate dentin and plaster of Paris alone or with alginate significantly improved the formation of new bone, both quantitatively and qualitatively. The oligosaccharide treatment appeared to improve the formation of new bone quantitatively and qualitatively.


MeSH Terms

Calcium Sulfate*
Dentin*
Free Radicals
Humans
Oligosaccharides
Osteogenesis
Transplants
Calcium Sulfate
Free Radicals
Oligosaccharides
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