J Korean Soc Radiol.  2011 May;64(5):475-479. 10.3348/jksr.2011.64.5.475.

Presacral Primary Well Differentiated Neuroendocrine Carcinoma: Case Report

• Lee JE
• Shin KS
• Cho JS
• Kang DY
• Kim JY

• KMID: 2040816
• DOI: http://doi.org/10.3348/jksr.2011.64.5.475

Abstract

Primary well-differentiated neuroendocrine carcinoma of the presacral region is extremely rare with only 19 case reports having been described in the literature. We report here the computed tomography and magnetic resonance imaging correlated with histopathologic findings of primary well-differentiated neuroendocrine carcinoma of the presacral region. Unlike the previously reported cases, our case exhibited aggressive behavior and distant metastases.

MeSH Terms

Carcinoid Tumor
Carcinoma, Neuroendocrine
Magnetic Resonance Imaging
Neoplasm Metastasis
Tomography, X-Ray Computed

Figure

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  Fig. 1 A 65-year-old man with primary well-differentiated neuroendocrine carcinoma of the presacral region. A. Unenhanced pelvic MDCT with bone setting shows an eccentric tiny calcification of the mass in the presacral region (curved arrow). B, C. T1- and T2- oblique axial MR images show a well-preserved fat plane (asterisk) between the rectum and the mass (arrows). D. Contrast-enhanced sagittal T1-weighted image shows heterogeneous enhancement of the mass. The mass tightly abuts to the levator ani muscle and coccyx with bone erosion. E. Photomicrograph of tumor cells shows round or fusiform cells arranged in sheets and rosette-like structure (Hematoxylin and eosin, ×100) F. Photomicrograph of tumor cells shows immunoreactivity for synaptophysin (synaptophysin immunohistochemical stain, × 100). G. After surgical excision of the primary neuroendocrine carcinoma, a follow-up PET/CT shows metastatic lymph nodes in both internal iliac regions (open arrows).

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