Korean J Hematol.
1997 Nov;32(3):440-445.
A Case of Unusual Clinical Course in Patient with Hemorrhagic Fever with Renal Syndrome Associated with Secondary Amyloidosis
- Affiliations
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- 1Department of Internal Medicine, Keimyung University, School of Medicine, Taegu, Korea.
- 2Department of Institute of Medical Cytogenetics, Keimyung University, School of Medicine, Taegu, Korea.
Abstract
- Hemorrhagic fever with renal syndrome (HFRS) is a symptom complex of fever, chill, myalgia, hemorrhagic diathesis and acute renal failure. We experienced a case of non-oliguric HFRS associated severe thrombocytopenia. Peripheral blood smear showed large atypical lymphocytosis and hemophagocytic histiocytes on bone marrow aspiration. Hantaan virus antibody titer was 1:5,120. Congo-red stain after potassium permanganate treatment of bone marrow biopsy revealed yellow-green birefringence and immunohistochemistry for AA amyloid antibody showed weak positive staining in the stroma of the bone marrow. Herein, we report a case of unusual HFRS associated with secondary amyloidosis and review the literature.
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