Korean J Hematol.  1997 Nov;32(3):419-422.

A Case of Factor VII Deficiency with Normal Factor VII Antigen Level

Affiliations
  • 1Department of Clinical Pathology, Catholic University Medical College, Seoul, Korea.
  • 2Department of Internal Medicine, Catholic University Medical College, Seoul, Korea.

Abstract

Factor VII (FVII) deficiency is a rare hereditary disorder with a reduced FVII:C activity, which is transmitted by an autosomal recessive gene with variable expressions and a high penetrance. FVII deficiency has different antigen levels, normal or reduced, and has various symptoms. We report on a 26 year-old male patient with pleurisy who showed hematuria and prolonged prothrombin time. FVII:C was 4% and FVII:Ag level was 80% (within normal range). The inheritance of this case is unclear. The FVII:C, FVII:Ag, and prothrombin time of his father and mother's sister were within normal ranges. This is the first proven case of FVII deficiency with normal FVII:Ag level in Korea.

Keyword

Factor VII deficiency; FVII:C; FVII:Ag; Prolonged prothrombin time

MeSH Terms

Adult
Factor VII Deficiency*
Factor VII*
Fathers
Genes, Recessive
Hematuria
Humans
Korea
Male
Penetrance
Pleurisy
Prothrombin Time
Reference Values
Siblings
Wills
Factor VII
Full Text Links
  • KJH
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr