Korean J Hematol.
2004 Dec;39(4):257-261.
A Case of Blastic Mantle Cell Leukemia
- Affiliations
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- 1Department of Laboratory Medicine, College of Medicine, University of Ulsan and Asan Medical Center, Seoul, Korea. cjpark@amc.seoul.kr
- 2Department of Internal Medicine, College of Medicine, University of Ulsan and Asan Medical Center, Seoul, Korea.
Abstract
- The Word Health Organization defines Mantle cell lymphoma (MCL), comprising two main morphological variant, blastoid and other variant. The classic type of blastoid variant show proliferation of lymphocytes, resembling lymphoblasts, with scant cytoplasm, rounded nuclei with fine dispersed chromatin and inconspicuous nucleoli. The blastoid variant is virtually indistinguishable from acute lymphoblastic leukemia based on blood and bone marrow morphology. We report one case of blastic mantle cell leukemia diagnosed by the immunophenotyping results and the detection of cyclin D1 overexpression on immunohistochemical stain.
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