Korean J Gastrointest Endosc.
2007 Nov;35(5):313-320.
Expression of TGF-beta1, TGF-beta Receptor Type II and VEGF in Colorectal Adenomas and Adenocarcinomas
- Affiliations
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- 1Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. drswnam@korea.com
- 2Department of Pathology, College of Medicine, Chungnam National University, Daejeon, Korea.
Abstract
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BACKGROUND/AIMS: The aim of study was to investigate the expression of TGF-beta, TGF-RII and VEGF determined by immunohistochemical analysis with a comparison of the clinicopathological parameters such as tumor size, grade of dysplasia, lymph node metastasis and Dukes' stage in colorectal adenomas and adenocarcinomas, by use of a tissue microarray method.
METHODS
The expression of TGF-beta1, TGF-betaRII, and VEGF was determined by immunohistochemistry in 20 adenomas and 40 adenocarcinomas. Tissue microarrays consisting of 2 mm cores from corresponding blocks were constructed and stained.
RESULTS
In adenomas, the staining intensity of TGF-beta, TGF-betaRII and VEGF was increased in a high-grade dysplasia group of patients as compared a with low-grade dysplasia group of patients, respectively. The staining intensity of TGF-betaRII was significantly increased in a high-grade dysplasia group of patients than a low-grade dysplasia group of patients (p =0.021). For the adenocarcinomas, the expression and staining intensity of TGF-beta1, TGF-betaRII and VEGF were increased as compared with the adenomas (p<0.001). However, no significant correlation was observed between the staining intensity of TGF-beta, TGF-betaRII and VEGF and the clinicopathological parameters.
CONCLUSIONS
The increased expression of TGF-beta1, TGF-betaRII and VEGF in colorectal adenocarcinoma suggests a role for these proteins in colorectal carcinogenesis. Loss of the growth-inhibitory effect of TGF-beta may commence in the early stage of colorectal carcinogenesis.
MeSH Terms
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Adenocarcinoma*
Adenoma*
Carcinogenesis
Humans
Immunohistochemistry
Lymph Nodes
Neoplasm Metastasis
Receptors, Transforming Growth Factor beta*
Transforming Growth Factor beta*
Transforming Growth Factor beta1*
Vascular Endothelial Growth Factor A*
Receptors, Transforming Growth Factor beta
Transforming Growth Factor beta
Transforming Growth Factor beta1
Vascular Endothelial Growth Factor A
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