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Immunohistochemical Study of TGF- type I and type II receptor Expression in Psoriatic Epidermis

Lee J, Kim YK, Koo SW, Choi GS

  • KMID: 2230357
  • Korean J Dermatol.
  • 2000 Sep;38(9):1205-1211.
BACKGROUND: Previous studies have demonstrated the pathogenetic role and expression of TGF-beta in psoriatic lesion. Transforming growth factor s are a family of growth factors with inhibitory effects on epithelial...
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Expression of growth factor, extracellular matrix and antioxidant (N-acetylcysteine) effect in TGF beta1 treated rat lens system

Park MS, Ahn CS, Hong YS

  • KMID: 2206311
  • J Korean Ophthalmol Soc.
  • 2002 Dec;43(12):2543-2554.
PURPOSE: The objective of this study was to characterize transdifferentiated lens epithelial cells analyzed by reverse transcription-polymerase chain reaction (RT-PCR) for the expression of mRNAs encoding growth factors, growth factor...
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Altered Expression of Transforming Growth Factor-beta1 and Its Receptors in Renal Cell Carcinoma

Kang SS, Min KD, Jung SI, Kim SY, Oh BR, Ryu SB, Park YI

  • KMID: 2172448
  • Chonnam Med J.
  • 2000 Dec;36(4):371-380.
PURPOSE: Resistance to the potent growth inhibitory effects of transforming growth factor-beta (TGF-beta) is a characteristic of many malignancies. TGF-beta insensitivity has been attributed to alterations in the number and...
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Effects of Transforming Growth Factor-beta1 and Its Receptor on the Development, Recurrence and Progression of Human Bladder Cancer

Quan C, Park MS, Jo SW, Lee SC, Kim WJ

PURPOSE: We investigated whether the expression levels of Transforming growth factor beta1 (TGF-beta1) and its receptors were related to the development, recurrence, progression and disease-free survival in the patients with...
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The Analysis of the Expression of TGF-beta in Human Hair Follicles in vivo

Won CH, Joo YH, Lee DH, An JS, Kim BJ, Kwon OS, Cho KH, Kim KH, Eun HC

  • KMID: 1931110
  • Korean J Dermatol.
  • 2007 Apr;45(4):321-326.
BACKGROUND: Although it is well known that transforming growth factor beta (TGF-beta) may induce catagen change of hair follicles and inhibit hair growth, it is still unclear which subtype of...
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Upregulation of Transforming Growth Factor-beta Receptors in the Rat Remnant Kidney

Kang MJ, Yoon HS, Chung MJ, Moon WS, Lee DG

  • KMID: 2254474
  • Korean J Nephrol.
  • 2001 Jan;20(1):9-15.
TGF-beta1 plays a major role in the regulation of extracellular matrix synthesis and degradation. TGF-beta1 exerts its biological effects by interacting with specific cell surface receptors including type I and...
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Expression of Transforming Growth Factor-beta1 and Its Receptors in N-butyl-N-(4-hydroxybutyl) Nitrosamine-induced Rat Bladder Carcinogenesis

Ryu SB, Oh KJ, Kwon DD, Oh BR, Kim SY, Choi IS, Choi C

  • KMID: 2293477
  • Korean J Urol.
  • 2003 Jun;44(6):599-605.
PURPOSE: To determine the role of TGF-beta1, and its receptors, in bladder tumor, their expressions at various stages of chemically-induced rat bladder carcinogenesis were investigated. MATERIALS AND METHODS: Forty female Sprague-Dawley...
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Expression of Transforming Growth Factor-beta Receptors in Food Protein-Induced Enterocolitis Syndrome in Infancy

Chung HL, Chung SM, Ha GA, Lee JJ, Choi EJ, Kim JG, Kim WT, Nho US, Hwang JB, Park JJ

  • KMID: 1994341
  • Pediatr Allergy Respir Dis.
  • 2002 Mar;12(1):36-43.
PURPOSE: Food protein-induced enterocolitis syndrome (FPIES) is a symptom complex of vomiting and diarrhea caused by non-IgE mediated allergy to cow's milk and/or soy in young infants. Transforming growth factor...
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Expression of the TGF-beta Family during the Development of Rat Eye

Kang KY, Baek JG, Kim H

  • KMID: 2092811
  • Korean J Anat.
  • 2003 Oct;36(5):417-426.
The development of eye is a very dynamic process in which various cells and tissues from diverse originneuroectoderm, surface ectoderm and mesenchyme, undergo induction, mitosis and differentiation. During this process...
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Effects of TGF-beta onthe HPC-16-induced Neoplastic Transformation of Human Cells

Park IS, Lee YS, Lee CH, Kim SS, Kim DH, Kim KS, Yang JH

  • KMID: 1928742
  • Korean J Gynecol Oncol Colposc.
  • 1997 Sep;8(3):243-249.
Human epithelial cell line immortalized with Ad12-SV40 hybrid virus was transfected with plasmid containing HPV-16 gene. Among these clones, clone-3 and clone-6 showed neoplastic transformation properties of contact inhibition, anchorage...
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Correlation between the Expression Levels of Transforming Growth Factor-beta (TGF-beta) Receptors and Responsiveness to TGF-beta1-Induced Growth Inhibitory Effects in Leukemic Cell Lines

Jeon JH, Park BK

  • KMID: 2083414
  • Korean J Hematol.
  • 2000 May;35(2):150-161.
BACKGROUND: Defects in TGF-beta receptors have been found in a variety of malignant cells, we therefore investigated whether these defects could be also demonstrated in leukemic cells. In addition, we...
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Effect of Transforming Growth Factor (TGF)-beta and Peroxisome Proliferator-Activated Receptor (PPAR)-gamma in Endometrial Decidualization

Kwon JH, Lee JH, Chang HJ, Park DW, Kim YA, Kim MR, Hwang KJ

  • KMID: 2077619
  • Korean J Obstet Gynecol.
  • 2006 Jun;49(6):1294-1303.
OBJECTIVE: To ascertain the expression of transforming growth factor (TGF)-beta receptors in normal human endometrium during the menstrual cycle, and the action of TGF-beta and peroxisome proliferator-activated receptor (PPAR)-gamma during...
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Expression of TGF-beta1, TGF-beta Receptor Type II and VEGF in Colorectal Adenomas and Adenocarcinomas

Kang SB, Lee SW, Kim YS, Nam SW, Lee DS, Kim JM, Han SW, Choi KY

  • KMID: 2038379
  • Korean J Gastrointest Endosc.
  • 2007 Nov;35(5):313-320.
BACKGROUND/AIMS: The aim of study was to investigate the expression of TGF-beta, TGF-RII and VEGF determined by immunohistochemical analysis with a comparison of the clinicopathological parameters such as tumor size,...
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The Clinical Significance of Transforming Growth Factor (TGF) beta1, TGF beta Receptor beta II, p53 Protein and K-ras Point Mutation in Pancreatic Cancer

Kim KS, Chae YS, Kim JT

  • KMID: 2211144
  • J Korean Surg Soc.
  • 2008 Apr;74(4):274-281.
PURPOSE: Many cancers, including pancreatic cancer, harbor defects in TGF beta signaling and are resistant to TGF beta mediated growth inhibition. In addition, the expression of the p53 gene and...
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The loss of expression of transforming growth factor-beta receptors correlates with the histopathologic tumor grade in bladder transitional cell carcinoma patients

Lee DH, Yang SC, Hong SJ, Chung BH, Chung HJ, Tokunaga H, Kim IY, Song YS, Lerner SP, Morton RA

Transforming growth factor-beta (TGF-beta), a pleiotropic growth factor, is a potent inhibitor of cellular proliferation in cells of epithelial origin. Recently, it has been suggested that a loss...
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The Effects of Anti-keloid Drugs on the Expressions of Fibronectin, Transforming Growth Factor-beta and Transforming Growth Factor-beta Receptor in Keloid Fibroblast

Park JM, Lee MH, Lee KC, Kim SK, Bae HR, Rha SH

  • KMID: 2334706
  • J Korean Soc Aesthetic Plast Surg.
  • 2005 Sep;11(2):229-236.
Keloids represent a dysregulated response to cutaneous wounding that results in an excessive deposition of extracellular matrix. However, the molecular mechanisms underlying this pathologic deposition of extracellular matrix still remain...
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Transforming Growth Factor-beta Type I Receptor Inhibitor Induces Functional and Morphologic Recovery in a Rat Model of Erectile Dysfunction and Cavernous Fibrosis

Ryu JK, Oh SM, Jin HR, Song KM, Kwon MH, Kim DK, Suh JK

PURPOSE: To examine the effectiveness of small-molecule inhibitor of transforming growth factor-beta (TGF-beta) type I receptor, an activin receptor-like kinase 5 (ALK5), on erectile dysfunction (ED) in a rat model...
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Peyronie's Disease: Current Medical Treatment and Future Perspectives

Ryu JK, Suh JK

PURPOSE: Because of our incomplete understanding of the pathogenesis of Peyronie's disease (PD), management of PD remains a therapeutic dilemma in the field of sexual medicine. Most currently available medical...
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Role of TGF-1 and TGF-beta Type II receptor in gastric cancer

Park DI, Son HJ, Song SY, Choe WH, Lim YJ, Park SJ, Kim JJ, Kim YH, Rhee PL, Paik SW, Rhee JC, Choi KW

  • KMID: 1985002
  • Korean J Med.
  • 2001 Oct;61(4):409-416.
BACKGROUND: Transforming growth factor-beta (TGF-beta) is a potent inhibitor of epithelial cell growth. However, carcinoma cells, unlike normal cells, can escape from negative regulation by TGF-beta through lack of expression...
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The Prognostic Significance of Chromosome 18 Monosomy in the Colon Cancer: Correlations with the Expressions of Smad4 and TGF-beta Receptor II Proteins

Choi YS, Lim HM, Kim BG, Lee TJ

  • KMID: 2211101
  • J Korean Surg Soc.
  • 2007 Sep;73(3):227-234.
PURPOSE: Chromosomal instability of chromosome 18 and inhibition of the transforming growth factor beta (TGF-beta) signaling pathway, which is mediated through Smad4, play important roles in the tumorigenesis of colon...
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