Korean J Urol.
1992 Apr;33(2):255-261.
Drug therapy in chilhood enuresis
- Affiliations
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- 1Department of Urology, Seoul National University, College of Medicine, Seoul, Korea.
Abstract
- We evaluated the results of drug therapy in 76 children with nocturnal enuresis, who were free of other abnormalities in screening tests. History taking, careful physical examination including back area. urinalysis, urine culture, KUB and uroflowmetry were the screening tests. Overall response rate was 69.7 %. We found no statistically significant differences in responses between primary and secondary enuresis to drug therapy. We also found no difference in response according to the drugs including imipramine hydrochloride alone, oxybutynin chloride alone and combining of both. There was no difference in the results of the presence or the absence of daytime frequency and urgency. Two patients who resisted to the long-term therapy of imipramine hydrochloride and oxybutynin chloride showed good responses to the administration of intra-nasal desmopressin acetate. These data suggest that oxybutynin chloride does not show better therapeutic results than imipramine hydrochloride, whereas desmopressin acetate may be used for intractable enuresis to conventional drug therapy.
