J Korean Med Sci.  2010 Feb;25(2):333-335. 10.3346/jkms.2010.25.2.333.

Use of Aripiprazole in Clozapine Induced Enuresis: Report of Two Cases

  • 1Department of Psychiatry, Incheon Christian Hospital, Incheon, Korea.
  • 2Department of Psychiatry, Inha University Hospital and College of Medicine, Incheon, Korea. kce320@inha.ac.kr


This report describes the efficacy of combined use of aripiprazole in the treatment of a patient with clozapine induced enuresis. Aripiprazole acts as a potential dopamine partial agonist and the dopamine blockade in the basal ganglia might be one of the causes of urinary incontinence and enuresis. We speculate that aripiprazole functioned as a D2 agonist in hypodopaminergic state of basal ganglia caused by clozapine and maintained dopamine level that would improve enuresis ultimately.


Clozapine; Enuresis; Aripiprazole; Dopamine

MeSH Terms

Antipsychotic Agents/*adverse effects
Clozapine/*adverse effects
Dopamine Agonists/*therapeutic use
Drug Therapy, Combination
Enuresis/chemically induced/*drug therapy
Middle Aged
Piperazines/*therapeutic use
Quinolones/*therapeutic use
Schizophrenia, Paranoid/drug therapy
Antipsychotic Agents
Dopamine Agonists


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