J Korean Med Sci.  2010 Feb;25(2):333-335. 10.3346/jkms.2010.25.2.333.

Use of Aripiprazole in Clozapine Induced Enuresis: Report of Two Cases

• Lee MJ
• Kim CE

• KMID: 1779273
• DOI: http://doi.org/10.3346/jkms.2010.25.2.333

Abstract

This report describes the efficacy of combined use of aripiprazole in the treatment of a patient with clozapine induced enuresis. Aripiprazole acts as a potential dopamine partial agonist and the dopamine blockade in the basal ganglia might be one of the causes of urinary incontinence and enuresis. We speculate that aripiprazole functioned as a D2 agonist in hypodopaminergic state of basal ganglia caused by clozapine and maintained dopamine level that would improve enuresis ultimately.

Keyword

Clozapine; Enuresis; Aripiprazole; Dopamine

MeSH Terms

Adult
Antipsychotic Agents/*adverse effects
Clozapine/*adverse effects
Dopamine/metabolism
Dopamine Agonists/*therapeutic use
Drug Therapy, Combination
Enuresis/chemically induced/*drug therapy
Humans
Male
Middle Aged
Piperazines/*therapeutic use
Quinolones/*therapeutic use
Schizophrenia, Paranoid/drug therapy
Antipsychotic Agents
Dopamine Agonists
Piperazines
Quinolones
Clozapine