Korean J Urol.  1993 Feb;34(1):51-54.

The effect of iodine solution for reducing mucosal secretion in augmentation ileocystoplasty in rats

• Yoon JY
• Hwang TK
• Park YH

Abstract

With the increasing use of intestinal segment for bladder substitutes or augmentation, excessive mucus secretions secreted by goblet cells in the transplanted intestinal mucosa elicits various problems in patients. During ileocystoplasty, three kinds of concentration of iodine solution (0.5 %, 0.25 %. 0.125 %) were applied on the mucosa of ileal segment for reducing mucosal secretion. 24-hour urine was collected for each rat weekly and then cystectomy was performed at 4 weeks after ileocystoplasry. The amount of lyophilizod dry mucus was increased in 2-3 weeks and decreased thereafter, and it was significantly lower in the group using 0.25 % iodine solution than in other groups. Fibrosis was not significant in all experimental rats compare to control group by Masson-trichromr staining. With this method further investigation will be needed for reducing the mucus secretion.

Keyword

Ileocystoplasty; Iodine solution; Reducing mucosal secretion

MeSH Terms

Animals
Cystectomy
Fibrosis
Goblet Cells
Humans
Intestinal Mucosa
Iodine*
Mucous Membrane
Mucus
Rats*
Urinary Bladder
Iodine