Nucl Med Mol Imaging.  2008 Dec;42(6):488-490.

Significant Mismatch between FDG Uptake and Size after Chemotherapy in a Patient with Non-small Cell Lung Cancer

• Kwon SY
• Jeong SY
• Seo YS
• Ha JM
• Chong A
• Oh JR
• Song HC
• Min JJ
• Bom HS

Abstract

A 75-year-old man with non-small cell lung cancer (NSCLC) underwent F-18 fluorodeoxyglucose (FDG) PET/CT for staging. PET/CT showed distant metastases to intra-abdominal lymph nodes (LNs) as well as bilateral mediastinal LNs (stage IV). He underwent PET/CT (restaging PET/CT) 1 week after the completion of first-line chemotherapy (docetaxel + carboplatin). It showed markedly increased FDG uptake in primary tumor, whereas tumor size decreased significantly, compared to prior PET/CT. This lesion was aggravated on follow-up CT 3 months after the completion of chemotherapy. Although there are several reports that FDG PET has potential to evaluate early response to chemotherapy and prognosis, there are a few cases to show mismatch between FDG uptake and size on PET/CT. Thus we report a case of NSCLC showed increased FDG uptake of primary tumor while decreased tumor size on restaging PET/CT.

Keyword

Non-small cell lung cancer; mismatch; FDG; size

MeSH Terms

Aged
Carcinoma, Non-Small-Cell Lung
Follow-Up Studies
Humans
Lymph Nodes
Neoplasm Metastasis
Prognosis