Korean J Anesthesiol.  2002 Oct;43(4):457-461. 10.4097/kjae.2002.43.4.457.

Effects of Gallamine, Vecuronium and Rocuronium on Oculocardiac Reflex, Blood Pressure and Heart Rate in Pediatric Strabismus Surgery

• Choi YK
• Park SW
• Kim DO

• KMID: 2033619
• DOI: http://doi.org/10.4097/kjae.2002.43.4.457

Abstract

BACKGROUND: Intraoperative oculocardiac reflex (OCR) is a common problem of pediatric strabismus surgery and potentially fatal as it can cause cardiac arrest. The goal of this study was to assess the effects of gallamine, vecuronium and rocuronium on the oculocardiac reflex, blood pressure and heart rate in pediatric strabismus surgery.
METHODS
Ninety healthy children undergoing strabismus surgery were randomly assigned to three groups; gallamine, vecuronium or rocuronium group. All children were under general anesthesia induced with thiopental sodium and received gallamine 3 mg/kg, vecuronium 0.1 mg/kg, or rocuronium 0.8 mg/kg as a muscle relaxant, and were maintained with sevoflurane in 50% nitrous oxide. Systolic blood pressure, diastolic blood pressure, and heart rate were measured before anesthesia, before the operation, before traction and after traction of the ocular muscle. The OCR was defined as a 20% or greater decrease in heart rate from before traction of the ocular muscle.
RESULTS
Compared with three groups, there were decreased incidences of OCR and increased heart rate at before the operation, before traction and after traction in the gallamine group (P<0.05). Systolic blood pressure and diastolic blood pressure were no differences occurred among three groups.
CONCLUSIONS
We found that the gallamine group results in decreased incidences of OCR and increased heart rate were comparable with three groups.

Keyword

Gallamine; oculocardiac reflex; rocuronium; vecuronium

MeSH Terms

Anesthesia
Anesthesia, General
Blood Pressure*
Child
Gallamine Triethiodide*
Heart Arrest
Heart Rate*
Heart*
Humans
Incidence
Nitrous Oxide
Reflex, Oculocardiac*
Strabismus*
Thiopental
Traction
Vecuronium Bromide*
Gallamine Triethiodide
Nitrous Oxide
Thiopental
Vecuronium Bromide