Korean J Clin Pathol.  1999 Aug;19(4):392-395.

A Case of Congenital Mature B Cell Lymphoblastic Leukemia

• Shin MG
• Suh SP
• Ryang DW

Abstract

The patient was a 1-day-old female with full term normal vaginal delivery. Petechiae and purpura were noted on body surface at birth. She did not have mongoloid face and hand-foot deformity. The skin nodules were bluish to slate-grey in color, and observed on all body surfaces. Hepatosplenomegaly was also noticed. Peripheral blood smear showed marked leukocytosis (109,400/microliter), thrombocytopenia (16,000/microliter) and leukoerythroblastosis. VDRL and TORCH tests were negative. The bone marrow was replaced by leukemic lymphoblasts. The normal hematopoietic cells were depleted. The leukemic lymphoblasts expressed markers of mature B cell differentiation, negative for Sudan black B, peroxidase, and positive for PAS (en bloc pattern) stain. Skin biopsy specimen showed diffuse infiltration of the leukemic cells. The diagnosis was congenital mature B cell lymphoblastic leukemia. This patient died at 7 days after birth.

Keyword

Congenital leukemia; B cell

MeSH Terms

Biopsy
Bone Marrow
Cell Differentiation
Congenital Abnormalities
Diagnosis
Female
Humans
Leukocytosis
Parturition
Peroxidase
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Purpura
Skin
Sudan
Thrombocytopenia
Peroxidase