Korean Circ J.  2001 Aug;31(8):780-787. 10.4070/kcj.2001.31.8.780.

A Randomized Comparison of Cilostazol Versus Ticlopidine Therapy After Elective Coronary Stent Implantaion

• Song JH
• Yoon C
• Rhee I
• Jung JY
• Jo KH
• Kim DI
• Kim DS

• KMID: 2029565
• DOI: http://doi.org/10.4070/kcj.2001.31.8.780

Abstract

BACKGROUND
Percutaneous transluminal coronary angioplasty(PTCA) is a widely acceptable treatment for ischemic heart disease. Restenosis after successful PTCA, which develops in 20~30% of all patients, remains a serious late complication. This study was to evaluate the efficacy of cilostazol for the prevention of stent restenosis compared with ticlopidine. MATERIALS AND METHOD: Fifty three patients underwent coronary stent implantation were divided in to as group A(n=25) receiving 100mg aspirin and 200mg cilostazol and group B(n=28) receiving 100mg asprine and 500mg ticlopidine from Sep 1998 and Feb 1999 at Pusan Paik Hospital, Inje University. Clinical and laboratory evaluations were preformed at regular interval. RESULT: There were no differences in baseline characteristics between the two groups. Coronary artery restenosis was observed in 5(20.8%) in group A and 8(26%) in group B respectively, which were not statistically significant (p=NS). Minimal luminal diameter was 2.10+/-0.89mm in group A and 1.93+/-0.65mm in group B (p=NS). Two patients in group A had headache, while 6(21.4%) patients of group B developed side effects including thrombocytopenia in 2 patients, skin rash in 2 patents . There was no cardiac death during the follow-up period.
CONCLUSION
Aspirin plus cilostazol may be safer and equally antithrombotic regimen compared results to aspirin plus ticolpidine after elective coronary stent implantation.

Keyword

Coronary artery stent; Restenosis; Cilostazol; Ticlopidine

MeSH Terms

Aspirin
Busan
Coronary Vessels
Death
Exanthema
Follow-Up Studies
Headache
Humans
Myocardial Ischemia
Phenobarbital
Stents*
Thrombocytopenia
Ticlopidine*
Aspirin
Phenobarbital
Ticlopidine