Korean J Blood Transfus.
2014 Aug;25(2):152-159. 10.0000/kjbt.2014.25.2.152.
Membranous Nephropathy Concurrent with Interstitial Nephritis after Allogenic Hematopoietic Stem Cell Transplantation in a Patient with Acute Lymphoblastic Leukemia
- Affiliations
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- 1Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jungeun34.lee@samsung.com
- 2Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- KMID: 2029271
- DOI: http://doi.org/10.0000/kjbt.2014.25.2.152
Abstract
- Kidney is rarely an involved organ of graft-versus-host disease (GVHD). Here, we report on a case of membranous nephropathy and interstitial nephritis after allogenic hematopoietic stem cell transplantation (HSCT) in a 44-year-old female patient with acute lymphoblastic leukemia. The patient received GVHD prophylaxis with low dose steroid, cyclosporin, and short course methotrexate. Cyclosporine was tapered out 17 months after allogeneic HSCT. Thereafter, the patient developed kidney impairment and nephrotic range proteinuria. Kidney biopsy revealed membranous nephropathy concurrent with interstitial nephritis.
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