Korean J Biol Psychiatry.  2012 Aug;19(3):128-133.

Association Analysis of Neuregulin 3 Gene with Schizophrenia in a Korean Population

• Shin S
• Choi JT
• Kim JW
• Roh YH
• Park BL
• Bae JS
• Shin HD
• Choi IG
• Han SW
• Hwang J
• Woo SI

Abstract

OBJECTIVES
Located on chromosome 10q22-q23, the human neuregulin 3 (NRG3) is suggested as a strong positional and functional candidate gene involved in the pathogenesis of schizophrenia. Several case-control studies examining the association between polymorphisms on NRG3 gene with schizophrenia and/or its traits (such as delusion) have been reported recently in cohorts of Han Chinese, Ashkenazi Jews, Australians, white Americans of Western European ancestry and Koreans. Thus, this study aimed to investigate the association of one SNP in exon 9 (rs2295933) of NRG3 gene with the risk of schizophrenia in a Korean population.
METHODS
Using TaqMan assay, rs2295933 in the exon 9 of NRG3 was genotyped in 435 patients with schizophrenia as cases and 393 unrelated healthy individuals as controls. Differences in frequency distributions were analyzed using logistic regression models following various modes of genetic inheritance and controlling for age and sex as covariates.
RESULTS
Subsequent analysis revealed that the frequency distribution of rs2295933 of NRG3 was not different between schizophrenia patients and healthy controls of Korean ethnicity.
CONCLUSIONS
This study does not support the role of NRG3 in schizophrenia in a Korean population.

Keyword

NRG3; Schizophrenia; Single nucleotide polymorphism; rs2295933

MeSH Terms

Asian Continental Ancestry Group
Case-Control Studies
Cohort Studies
Exons
Humans
Jews
Logistic Models
Polymorphism, Single Nucleotide
Schizophrenia
Wills