Genomics Inform.  2014 Jun;12(2):76-78. 10.5808/GI.2014.12.2.76.

SFannotation: A Simple and Fast Protein Function Annotation System

• Yu DS
• Kim BK

• KMID: 2026466
• DOI: http://doi.org/10.5808/GI.2014.12.2.76

Abstract

Owing to the generation of vast amounts of sequencing data by using cost-effective, high-throughput sequencing technologies with improved computational approaches, many putative proteins have been discovered after assembly and structural annotation. Putative proteins are typically annotated using a functional annotation system that uses extant databases, but the expansive size of these databases often causes a bottleneck for rapid functional annotation. We developed SFannotation, a simple and fast functional annotation system that rapidly annotates putative proteins against four extant databases, Swiss-Prot, TIGRFAMs, Pfam, and the non-redundant sequence database, by using a best-hit approach with BLASTP and HMMSEARCH.

Keyword

bioinformatics; gene product; protein annotation

MeSH Terms

Computational Biology
Databases, Protein
Molecular Sequence Annotation