J Korean Soc Coloproctol.  1998 Jun;14(2):317-322.

A Case of Hydrogen Peroxide Enema Induced Chemical Colitis

• Lee SC
• Yoo JG
• Park HS
• Lee JD
• Jin CJ
• Kim BG
• Park UC
• Park EU

Abstract

Hydrogen peroxide solution is commonly used for irrigating and cleaning wounds. When it is applied to tissues, catalase causes its rapid molecular degeneration with the release of oxygen bubbles. We present case report illustrating two hazards ; chemical colitis and oxygen embolus. A 29-year-old previously healthy woman presented to the bloody diarrhea and anal pain after hydrogen peroxide enema. In the colonoscopic examination, severe mucosal edema and ulceration with bleeding was noted from anus to sigmoid colon. With use of anal endosonography, multiple high level echo were noted in the internal and external anal sphincter of the upper anal canal. Microscopically, mononuclear cells were infiltrated in lamina propria and congestion. She had treatment with IV fluid, IV antibiotics and NPO. At 3rd hospital day, anal pain was disappeared. Bloody stool was disappeared next day. At 8th hospital day, mucosal edema and ulceration were disappeared on colonoscopic examination. Recovery was full and the patient was discharged at nine days after the episode.

Keyword

en buHydrogen peroxide; Chemical colitis; Oxygbble

MeSH Terms

Adult
Anal Canal
Anti-Bacterial Agents
Catalase
Colitis*
Colon, Sigmoid
Diarrhea
Edema
Embolism
Endosonography
Enema*
Estrogens, Conjugated (USP)
Female
Hemorrhage
Humans
Hydrogen Peroxide*
Hydrogen*
Mucous Membrane
Oxygen
Ulcer
Wounds and Injuries
Anti-Bacterial Agents
Catalase
Estrogens, Conjugated (USP)
Hydrogen
Hydrogen Peroxide
Oxygen