J Korean Radiol Soc.  1994 Dec;31(6):1017-1027.

An Experimental Study on Transcatheter Embolization With Mixture of Ethanolamine Oleate and Microfibrillar Collagen in Rabbits

• Han MH
• Goo JM
• Chang KH
• Yeon KM
• Yu IK
• Yoon DY

Abstract

PURPOSE
To evaluate ethanolamine oleate (EAO)-microfibrillar collagen (MFC) mixture as a new scleroembolic material for the interventions requiring both permanent obliteration of vascular lumen and atrophy of mass, such as for the facial AVM and other hypervascular soft tissue masses.
MATERIALS AND METHODS
Twenty-nine transcatheter transarterial embolizations of renal arteries were performed in six groups of rabbits classified by the EAO concentration and the addition of MFC. Postembolization angiography, gross morphological and microscopic examinations of embolized kidneys were performed immediately, 3 days, 2 weeks and 4 weeks after embotization. Analysing points were the usefulness as a scleroembolic material (endovascular retention, thrombogenic-sclerosing effect, perivascular fibrosis and inflammatory reaction), effects of the EAO concentration and the addition of MFC.
RESULTS
EAO-MFC mixture satisfied all ideal conditions of scleroembolic agent;persistent endovascular retention, good thrombogenic-sclerosing effect with a mild inflammatory reaction and significant atrophy of kidney. The effect of increasing concentration of EAO was proximal embolization. The effects of MFC were promotion of proximal embolization, endovascular retention and sclerosing effect.
CONCLUSION
EAO-MFC mixture can be used as a new effective scleroembolic material for the various hemodynamic situations in which embolic level can be controlled by EAO concentration and the addition of MFC.

MeSH Terms

Angiography
Atrophy
Collagen*
Ethanolamine*
Fibrosis
Hemodynamics
Kidney
Oleic Acid*
Rabbits*
Renal Artery
Collagen
Ethanolamine
Oleic Acid