Novalis Radiosurgery of Primary Central Nervous System Lymphoma in Elderly Patients: Preliminary Results

Han, Seong Rok; Yee, Gi Taek; Choi, Chan Young; Sohn, Moon Jun; Lee, Dong Joon; Whang, Choong Jin

Abstract

OBJECTIVE
Primary central nervous system lymphoma(PCNSL) is a non-Hodgkin's lymphoma arising in the central nervous system. Combined chemotherapy and radiation therapy is the standard treatment for PCNSL. However, treatment induced neurotoxicity is a major problem especially in elderly patients.
METHODS
From May 2001 to April 2004, elderly five patients with PCNSL confirmed via pathological examination were underwent Novalis radiosurgery in authors' institution, who were investigated retrospectively. Of these patients, 2 were male and 3 were female, with a mean age 68 years old (range 65~73). The number of lesions was 1 in 2 patients, 2 in 2, and 3 in 1. The mean follow up period was 12.6 months (range 8~16).
RESULTS
Clinical symptoms and signs in all patients markedly improved within 1 weeks after Novalis radiosurgery. The Karnofsky performance status score was also improved from a pre-radiosurgery average of 68 to a post-radiosurgery one of 82. All of treated lesions showed a partial or complete regression of the original mass. There have been no complication following Novalis radiosurgery.
CONCLUSION
The preliminary results of our experience indicate that radiosurgery with Novalis provides a safe and effective therapeutic alternative treatment of PCNSL in elderly patients.