J Korean Neuropsychiatr Assoc.
1998 Jan;37(1):186-193.
A Cabe of Clozapine-Induced Agranulocytosis
- Affiliations
-
- 1Department of Neuropsychiatry, Sanggye Paik Hospital, Inje University Medical College, Seoul, Korea.
Abstract
- We report a 20-year-old female patient who developed clozapine-induced agranulocytosis on the 29th day of clozapine treatment. She recovered from the agranulocytosis on the 8th day of progression after treatment with G-CSE, GM-CSF, antibiotics and associated aseptic procedures. The cause of clozapine-induced agranulocytosis is still un known and it is proposed that the dominant gene of major histocompatibility complex region and the reactive metabolites which suppress the myeloid system may be responsible. We recommend that careful attentions such as the selection of patient, evaluation of the risk factors, and the thorough control of CPMS should be paid. If the agranulocytosis happens, it is helpful to consult to the department of medicine immediately.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Granulocyte-Colony Stimulating Factor(G-CSF) Treatment of Clozapine-induced Agranulocytosis
- Clozapine-induced Agranulocytosis
- Three Cases of Reversible Agranulocytosis after Treatment with Lamotrigine
- Treatment of Clozapine-Induced Agranulocytosis Associated with Complications
- Late Onset Agranulocytosis with Clozapine Associated with HLA DR4 Responding to Treatment with Granulocyte Colony-stimulating Factor: A Case Report and Review of Literature
