J Korean Neuropsychiatr Assoc.  1998 Jan;37(1):174-179.

How to Determine P300 Component in Auditory Event Related Potential Brain Topography

Affiliations
  • 1Department of Neuropsychiatry, Our Lady of Mercy Hospital, the Catholic University of Korea, Seoul, Korea.

Abstract

OBJECTS: This study was designed to make a comparison between methods to determine the components of topographic auditory event related potential P300.
METHODS
The subjects were consisted of 44 normal controls and 44 patients with schizophrenia diagnosed by DSM-IV. The topographic auditory event related P300 was recorded in oddball paradigm. The components of P300, including latency, amplitude, and location of maximum amplitude in X-Y coordinates, were analized by computerized EP mapping system. The latency of P300 was determined by both global field power measurement and classic method.
RESULTS
There was difference between two groups in latency(DF=1, F=35.28, P= 0.0001) and amplitude(DF=1, F=36.62, P=0.0001), but not in X coordinate(DF=1, F=0.37, P=0.55) and Y coordinate(DF=1, F=2.00, P=0.16). There was no difference between two mothods in latency(DF=1, F=0.04, P=0.85), in amplitude(DF=1, F=0.07, P=0.79), in X coordinate(DF=1, F=0.07, P=0.79), and in Y coordinate(DF=1, F=0.03, P=0.86).
CONCLUSION
The results suggested that two methods to determine the components of topographic auditory event related potential P300 should be available for both research and clinical application to date.

Keyword

Global field power measurement(GFPM); Classical method(CM); Event related potential(ERP); P300; Topography

MeSH Terms

Brain*
Diagnostic and Statistical Manual of Mental Disorders
Event-Related Potentials, P300*
Humans
Schizophrenia
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