J Korean Neuropsychiatr Assoc.  2004 Sep;43(5):577-582.

Cognitive Dysfunctions in Patients with Obsessive-Compulsive Disorder: Two-Year Treatment Follow-up

• Roh KS
• Shin MS
• Park HS
• Ha TH
• Shin YW
• Kim MS
• Kwon JS

Abstract

OBJECTIVES
The purpose of this study was to investigate the changes of cognitive dysfunctions in patients with obsessive compulsive disorder (OCD) over the two-year of pharmacological treatment.
METHODS
The thirty-three OCD patients and thirteen normal subjects were administered the neuropsychological tests and clinical evaluations twice (at the baseline and two-year).
RESULTS
In spite of the two-year treatment, the accuracy of delayed recall on the Rey-Osterrieth Complex Figure Tests (RCFT), the numbers of responses on the category and letter test of Controlled Oral Word Association Test (COWA), the response time on the Trail Making Test part A (TMT-A) remained significantly impaired in the OCD patients compared with the normal controls.
CONCLUSION
These findings suggest that the cognitive dysfunctions such as visuospatial memory and verbal fluency might be the underlying persisting neuropathophysiology of OCD.

Keyword

Obsessive-compulsive disorder; Rey-osterrieth complex figure tests; Controlled oral word association test; Cognitive dysfunctions

MeSH Terms

Follow-Up Studies*
Humans
Memory
Neuropsychological Tests
Obsessive-Compulsive Disorder*
Reaction Time
Trail Making Test
Word Association Tests