J Korean Neurol Assoc.
1990 Jun;8(1):14-20.
Responese of Serum Prolactin, Growth Hormone and Cortisol to Generalized Epileptic Seizures and to Stress
- Affiliations
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- 1Department of Neurology, College of Medicine, Seoul National University, Korea.
- 2Department of Internal Medicine, College of Medicine, Seoul National University, Korea.
Abstract
- We selected 9 epileptics, 9 stressed, and 9 normal men and tried to see how generalized seizures and nonspecific stress influence the levels of serum prolactin, GH and cortisol. Serum concentrations of above hormones, following spontaneous generalized seizures in epileptic men were compared with similar measurements made in nonepileptic stressed men to determine the role of stress in the hormonal response to seizures. Prolactin, GH and cortisol levels increased significantly within 60 min postictally, and peak levels occurred at about 20 min after seizures. Prolactin and GH were recovered to basal levels at 1-2 hours postictally, but cortisol concentrations were still elevated. 3 hours after seizures and showed delayed decline. Poststressed cortisol and GH levels were 4-5 times higher than basal levels, but prolactin concentrations did not rise significantly. In comparison of increments between epileptics and stressed men, prolactin ratios of epileptics were significantly higher than those of stressed, but GH ratios and cortisol differences were inclined to be higher in epileptics, without statistic significance.
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