J Periodontal Implant Sci.  2014 Jun;44(3):134-140. 10.5051/jpis.2014.44.3.134.

A randomized clinical trial to evaluate and compare the efficacy of triphala mouthwash with 0.2% chlorhexidine in hospitalized patients with periodontal diseases

Affiliations
  • 1Department of Periodontology, Tatyasaheb Kore Dental College & Research Centre, Kolhapur, India. ritam.nt@gmail.com

Abstract

PURPOSE
Triphala is a combination of three medicinal plants, extensively used in Ayurveda since ancient times. Triphala mouthwash is used in the treatment of periodontal diseases because of its antimicrobial and antioxidant properties. The aim of this study is to compare the efficacy of triphala mouthwash with 0.2% chlorhexidine in hospitalized periodontal disease patients.
METHODS
In this double-blind, randomized, multicenter clinical trial, 120 patients were equally divided into three groups. Patients in group A were advised to rinse their mouths with 10 mL of distilled water, group B with 0.2% chlorhexidine, and group C with triphala mouthwash for 1 minute twice daily for two weeks. The plaque index (PI) and the gingival index (GI) were recorded on the first and the fifteenth day.
RESULTS
There was no significant difference when the efficacy of triphala was compared with 0.2% chlorhexidine in hospitalized patients with periodontal disease. However, a statistically significant difference was observed in PI and GI when both group B and group C were compared with group A and also within groups B and C, after 15 days (P<0.05).
CONCLUSIONS
The triphala mouthwash (herbal) is an effective antiplaque agent like 0.2% chlorhexidine. It is significantly useful in reducing plaque accumulation and gingival inflammation, thereby controlling periodontal diseases in every patient. It is also cost effective, easily available, and well tolerable with no reported side effects.

Keyword

Chlorhexidine; Gingivitis; Periodontitis; Triphala

MeSH Terms

Chlorhexidine*
Gingivitis
Humans
Inflammation
Mouth
Periodontal Diseases*
Periodontal Index
Periodontitis
Plants, Medicinal
Water
Chlorhexidine
Water

Figure

  • Figure 1 Study design flow chart. Group A: patients were advised to rinse their mouths with 10 mL of distilled water for 1 minute twice daily for two weeks, group B: patients were advised to rinse their mouths with 0.2% chlorhexidine for 1 minute twice daily for two weeks, group C: patients were advised to rinse their mouths with triphala mouthwash for 1 minute twice daily for two weeks.

  • Figure 2 Bar diagram showing comparison of mean plague index (PI) and gingival index (GI) values for the three groups. Group A: patients were advised to rinse their mouths with 10 mL of distilled water for 1 minute twice daily for two weeks, group B: patients were advised to rinse their mouths with 0.2% chlorhexidine for 1 minute twice daily for two weeks, group C: patients were advised to rinse their mouths with triphala mouthwash for 1 minute twice daily for two weeks.


Reference

1. Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000. 1994; 5:78–111.
Article
2. Axelsson P. In : Lang N, Karring T, editors. Mechanical plaque control. Proceedings of the 1st European workshop on periodontics, 1993; London: Quitessence;1994. p. 219–243.
3. Eley BM. Antibacterial agents in the control of supragingival plaque: a review. Br Dent J. 1999; 186:286–296.
Article
4. Nagappan N, John J. Antimicrobial efficacy of herbal and chlorhexidine mouth rinse: a systematic review. J Dent Med Sci. 2012; 2:5–10.
5. Addy M, Moran JM. Evaluation of oral hygiene products: science is true; don't be misled by the facts. Periodontol 2000. 1997; 15:40–51.
Article
6. Asadoorian J. Oral rinsing. Can J Dent Hyg. 2006; 40:1–13.
7. Loe H, Schiott CR. The effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in man. J Periodontal Res. 1970; 5:79–83.
Article
8. Imfeld T. Chlorhexidine-containing chewing gum. Clinical documentation. Schweiz Monatsschr Zahnmed. 2006; 116:476–483.
9. Van Leeuwen MP, Slot DE, Van der. Essential oils compared to chlorhexidine with respect to plaque and parameters of gingival inflammation: a systematic review. J Periodontol. 2011; 82:174–194.
Article
10. Rolla G, Loe H, Schiott CR. Retention of chlorhexidine in the human oral cavity. Arch Oral Biol. 1971; 16:1109–1116.
Article
11. Adams D, Addy M. Mouthrinses. Adv Dent Res. 1994; 8:291–301.
Article
12. Flotra L, Gjermo P, Rolla G, Waerhaug J. Side effects of chlorhexidine mouth washes. Scand J Dent Res. 1971; 79:119–125.
Article
13. Overholser CD Jr. Longitudinal clinical studies with antimicrobial mouthrinses. J Clin Periodontol. 1988; 15:517–519.
Article
14. Addy M. Chlorhexidine compared with other locally delivered antimicrobials: a short review. J Clin Periodontol. 1986; 13:957–964.
Article
15. Bose S, Sinha SK, Mukherjee G. In-vitro study of triphala on antioxidant activity. Sci Cult. 2011; 77:511–513.
16. Surya Prakash DV, Sree Satya N, Avanigadda S, Vangalapati M. Pharmacological review on Terminalia chebula. Int J Res Pharm Biomed Sci. 2012; 3:679–683.
17. Dar PA, Sofi G, Parray SA, Jafri MA. Halelah siyah (Terminalia chebula retz): in unani system of medicine and modern pharmacology: a review. Int J Inst Pharm Life Sci. 2012; 2:138–149.
18. Vani T, Rajani M, Sarkar S, Shishoo CJ. Antioxidant properties of the Ayurvedic formulation Triphala and its constituents. Pharm Biol. 1997; 35:313–317.
Article
19. Padmawar A, Bhadoriya U. Phytochemical investigation and comparative evaluation of in vitro free radical scavenging activity of Triphala & Curcumin. Asian J Pharm Med Sci. 2011; 1:9–12.
20. Ariyaphong W, Kanjana J, Seewaboon S. Triphala: The Thai traditional herbal formulation for cancer treatment. Songklanakarin J Sci Technol. 2009; 31:139–149.
21. Malhotra R, Grover V, Kapoor A, Saxena D. Comparison of the effectiveness of a commercially available herbal mouthrinse with chlorhexidine gluconate at the clinical and patient level. J Indian Soc Periodontol. 2011; 15:349–352.
Article
22. Abraham S, Kumar MS, Sehgal PK, Nitish S, Jayakumar ND. Evaluation of the inhibitory effect of triphala on PMN-type matrix metalloproteinase (MMP-9). J Periodontol. 2005; 76:497–502.
Article
23. Desai A, Anil M, Debnath S. A clinical trial to evaluate the effects of triphala as a mouthwash in comparison with chlorhexidine in chronic generalized periodontitis patient. Indian J Dent Adv. 2010; 2:243–247.
24. Thomas B, Shetty SY, Vasudeva A, Shetty V. Comparative evaluation of antimicrobial activity of triphala and commercially available toothpastes: an in-vitro study. Int J Public Health Dent. 2011; 2:8–12.
25. Biradar YS, Jagatap S, Khandelwal KR, Singhania SS. Exploring of antimicrobial activity of triphala Mashi-an Ayurvedic formulation. Evid Based Complement Alternat Med. 2008; 5:107–113.
Article
26. Griffiths J, Jones V, Leeman I, Lewis D, Patel K, Wilson K. Guidelines for the development of local standards of oral health care for dependent, dysphagic, critically and terminally ill patients. Revised. [London]: British Society for Disability and Oral Health;2000.
27. Sumi Y, Nakamura Y, Nagaosa S, Michiwaki Y, Nagaya M. Attitudes to oral care among caregivers in Japanese nursing homes. Gerodontology. 2001; 18:2–6.
Article
28. Leyes Borrajo JL, Garcia VL, Lopez CG, Rodriguez-Nunez I, Garcia FM, Gallas TM. Efficacy of chlorhexidine mouthrinses with and without alcohol: a clinical study. J Periodontol. 2002; 73:317–321.
Article
29. Santos A. Evidence-based control of plaque and gingivitis. J Clin Periodontol. 2003; 30:Suppl 5. 13–16.
Article
30. Gupta M. Therapeutic uses of the polyherbal drug triphala in geriatric diseases. Int J Pharm Bio Sci. 2010; 1:1–13.
31. Maurya DK, Mittal N, Sharma KR, Nath G. Role of triphala in the management of peridontal disease. Anc Sci Life. 1997; 17:120–127.
32. Bajaj N, Tandon S. The effect of triphala and chlorhexidine mouthwash on dental plaque, gingival inflammation, and microbial growth. Int J Ayurveda Res. 2011; 2:29–36.
Article
33. Narayan A, Mendon C. Comparing the effect of different mouthrinses on de novo plaque formation. J Contemp Dent Pract. 2012; 13:460–463.
Article
34. Jagadish L, Anand Kumar VK, Kaviyarasan V. Effect of triphala on dental bio-film. Indian J Sci Technol. 2009; 2:30–33.
Article
35. Tandon S, Gupta K, Rao S, Malagi KJ. Effect of triphala mouthwash on the caries status. Int J Ayurveda Res. 2010; 1:93–99.
Article
36. Axelsson P, Lindhe J. Efficacy of mouthrinses in inhibiting dental plaque and gingivitis in man. J Clin Periodontol. 1987; 14:205–212.
Article
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