Korean J Urol.  1960 Oct;1(2):105-110.

Influence of Hepatic Damage on the Male Reproductive Glands: III. Influence of Hepatic Damage on the Effect of Exogenous Sex Hormones on the Reproductive Glands of White Castrated Rats

• Kim YK
• Lee HS

Abstract

Young adult male white rats were castrated to remove the main source of production of sex hormones in the body. Carbon tetrachloride was injected to induce damage to the liver in two groups of animals. The effect of hepatic damage on the histological and biological activity of exogenous sex hormones on the accessory glands of reproduction was observed. Castration causes a very remarkable decrease in the weight of the accessory glands of reproduction. Exogenous androgen restored the glands to normal. Hepatic damage did not lay a role in the inactivation of exogenous androgen. A direct antagonism between the exogenous androgen and the exogenous estrogen seemed to be present and the hepatic damage did not play role to accelerate or suppress this action. Citric acid concentration in the prostatic tissue showed a sharp rise following castration but restoration of the gland by giving exogenous sex hormones returned the citric acid concentration to hormonal levels. The hepatic damage did not cause a rise in the citric and content when both androgens and estrogens were together. The concentration of the prostatic citrate can not be taken as an index of androgenic activity.

Keyword

liver cirrhosis; castration; male reproductive gla

MeSH Terms

Androgens
Animals
Carbon Tetrachloride
Castration
Citric Acid
Estrogens
Gonadal Steroid Hormones*
Humans
Liver
Liver Cirrhosis
Male*
Rats*
Reproduction
Young Adult
Androgens
Carbon Tetrachloride
Citric Acid
Estrogens
Gonadal Steroid Hormones