Korean J Urol.  1960 Oct;1(2):97-104.

Influence of Hepatic Damage on the Male Reproductive Glands: II. Influence of Hepatic Damage on the Effect of Exogenous Sex Hormones on the Reproductive Glands of White Rats

• Kim YK
• Lee HS

Abstract

Young adults male rats were injected with carbon tetrachloride to induce damage to the liver in order to study the influence of this damage on the effects of exogenous estrogens and androgens on the reproductive glands and their accessories. The liver damage by the toxin caused a marked decrease in the weights of the prostate and the seminal vesicles of the rat whereas there was no great alteration in testicular effect of exogenous androgen seemed not be significant whereas the effect of exogenous estrogen was greatly increased by the condition. Histological findings in the reproductive glands following hepatic damage are chiefly those of atrophic changes. Citric acid concentration in the prostatic tissue was not influenced by liver damage but estrogen administration caused a marked increase and estrogen with liver damage caused a sharper rise in the concentration. Citric acid content of prostatic tissue can not be taken as an index of androgenic activity.

Keyword

liver cirrhosis; citric acid; exogenous sex hormon

MeSH Terms

Androgens
Animals
Carbon Tetrachloride
Citric Acid
Estrogens
Gonadal Steroid Hormones*
Humans
Liver
Liver Cirrhosis
Male*
Prostate
Rats*
Seminal Vesicles
Weights and Measures
Young Adult
Androgens
Carbon Tetrachloride
Citric Acid
Estrogens
Gonadal Steroid Hormones