J Korean Assoc Oral Maxillofac Surg.  2001 Jun;27(3):204-208.

Analysis of PGE2 Concentration in Synovial Fluid Aspirates from TMJs of Patients with Mandibular Fracture

• Lee GH
• Kim SG
• Kim MS

Abstract

The purpose of this study is to examine the change of enzymeimmuno-assay for prostaglandinE2 in the synovial fluid lavage specimen of patients with mandibular fracture patients without condylar fracture. For this study, fourteen patients (eight males, six females) with mandibular fractures without condylar fracture was investigated to analyse the synovial fluid from upper temporomandibular joint cavities. Synovial fluid was collected from TMJ cavities of mandibular fracture patients before open reduction and after one week of open reduction, and then stored in liquid nitrogen tank after centrifuge. Two synovial fluid lavage samples of TMJs of 2 asymptomatic served as normal controls referred from other data. The concentrations of PGE2 were measured by use of PGE2 EIA system (Amersham). The following results were obtained: 1) In nine patients, the concentrations of PGE2 are lower after open reduction than before. 2) In three patients, the concentrations of PGE2 are higher after open reduction than before. 3) There was no statistical significant between the preoperative group and postoperative 7 days (p>0.05), but there was some difference between the two groups. In conclusion, the results suggest that PGE2 probably does not play as important role in the harm of TMJ.

MeSH Terms

Dinoprostone*
Humans
Male
Mandibular Fractures*
Nitrogen
Synovial Fluid*
Temporomandibular Joint*
Therapeutic Irrigation
Dinoprostone
Nitrogen