J Korean Assoc Maxillofac Plast Reconstr Surg.  2010 Jan;32(1):16-22.

EFFECT OF SHORT ADMINISTRATION BISPHOSPHONATE TO PERIOSTEUM AND SINUS MEMBRANE AFTER ILIAC BONE GRAFT INTO MAXILLARY SINUS IN RABBIT

Affiliations
  • 1Department of Oral and Maxillofacial Surgery, Pusan Paik hospital, Inje University, Korea. lsu0122@hotmail.com

Abstract


OBJECTIVE
Bisphosphonate related osteonecrosis of the jaw (BRONJ) is reported in patients taken bisphosphonate for a long time, however, the mechanism of osteonecrosis in BRONJ was not clarified yet. This study was designed to investigate the effect of short administraion zoledronate on the healing pattern of periosteum and sinus membrane after iliac bone graft into maxillary sinus.
METHODS
In this study, 18 Newzeland rabbits were used. The animals were divided into 2 group. In the experimental group, rabbits were treated with weekly peritoneal injection (0.06 mg/kg/week) of zoledronate for three times. In the control group, rabbits were treated with saline solution injection instead of zoledronate. Periosteum and sinus membrane were harvested from one rabbit of the experimental group and one of the control group in the fourth week. The autogeneous bone was harvested from ilium and grafted into maxillary sinus. The rabbits were sacrificed at 1, 2, 4 and 8 weeks after bone graft. The healing pattern of periosteum and sinus membrane were evalulated histologically.
RESULTS
Inflammatory reaction in the periosteum was less conspicuous and healing process appeared earlier in experimental group compared with control group at 1, 2, 4 weeks. There were no differences of microscopic findings of sinus membrane between both groups at any weeks.
CONCLUSION
Short-term use of zoledronate decreased the inflammatory reaction and enhanced healing process in the periosteum. These findings suggest the possibility that zoledronte suppress the function of macrophages.

Keyword

Zoledronate; Sinus bone graft; Periosteum; Sinus membrane

MeSH Terms

Animals
Bisphosphonate-Associated Osteonecrosis of the Jaw
Diphosphonates
Humans
Ilium
Imidazoles
Macrophages
Maxillary Sinus
Membranes
Osteonecrosis
Periosteum
Rabbits
Sodium Chloride
Transplants
Diphosphonates
Imidazoles
Sodium Chloride
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