J Korean Soc Transplant.
2000 Jun;14(1):109-114.
A Case of Immune Hemolytic Anemia after Renal Transplantation
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
- 2Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
Abstract
- Several cases of immune hemolytic anemia have been reported after renal transplantation of ABO-minor-mismatch. We present a case of anti-B immune hemolytic anemia which developed on 11th day after renal transplantation. 48-year-old man, blood group Rh(+) AB, had a successful renal transplantation from his distant family, blood group Rh(+) A. He was maintained under immunosuppression with cyclosporine and prednisolone. On 11th day after renal transplantation he had a hemolytic episode. His hemoglobin dropped from 9.2 g/dl to 7.3 g/dl and corrected reticulocyte count increased to 3.7%. The peripheral blood morphology showed polychromatophilia, spherocytosis, and anisocytosis. Direct antiglobulin tests were positive with anti-IgG and anti-C3d. The antibody that caused hemolytic anemia was confirmed as anti-B IgG. The anti-B antibodies might be originated from passenger's donor B lymphocyte.
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