J Korean Soc Transplant.  2006 Jun;20(1):110-116.

Auxiliary Partial Orthotopic Liver Transplantations for One Pediatric Patient with Complement Factor H Deficiency and Two Adult Patients

• Suh KS
• Lee HW
• Cho EH
• Yang SH
• Cho JY
• Cho YB
• Yi NJ
• Lee KU

Abstract

We have performed 3 cases of APOLT in one child and two adults. The child recipient had suffered from complement factor H deficiency since 3 months after birth and at the age of 30 months, APOLT was undertaken. Living donors of two adult recipients were affected by severe hepatic steatosis and the grafts were relatively small-for-size. After left hemihepatectomies, left lateral section and left hemilivers were transplanted orthotopically. The child recipient died of heart failure due to sepsis 7 months after transplantation, but factor H level remained nearly normal until his death. Although one adult suffered from hepatic venous stricture postoperatively, all adult recipients are alive with normal liver function for 11 and 8 months. In conclusion, although APOLT is technically demanding, APOLT may be a suitable surgical procedure in non-cirrhotic metabolic liver disease and a feasible solution for marked steatotic living donor grafts and small-for-size grafts.

Keyword

Auxiliary partial orthotopic liver transplantation (APOLT); Complement factor H deficiency; Steatosis; Indication

MeSH Terms

Adult*
Child
Complement Factor H*
Complement System Proteins*
Constriction, Pathologic
Heart Failure
Humans
Liver Diseases
Liver Transplantation*
Liver*
Living Donors
Parturition
Sepsis
Transplants
Complement Factor H
Complement System Proteins