J Korean Soc Magn Reson Med.  2011 Aug;15(2):139-145. 10.13104/jksmrm.2011.15.2.139.

Acute Adverse Reactions to Gadolinium-based Intravenous Contrast Agents for MRI : Retrospective Analysis Using Computed Reporting System

Affiliations
  • 1Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea. dumkycji@gmail.com

Abstract

PURPOSE
To assess the frequency and severity of acute adverse reactions to intravenous administration of gadolinium-based contrast agents using computerized reporting system at a single large academic institution.
MATERIALS AND METHODS
We assessed data from electronic hospital information system from October 2008 to December 2010. Reactions were classified as mild, moderate, or severe. We compared the frequency of adverse reactions among three contrast agents (Gd-BT-DO3A, Gd-DTPA and Gd-EOB-DTPA).
RESULTS
The total number of administrated contrast agents was 33,600, and the number of administration of Gd-BT-DO3A, Gd-DTPA and Gd-EOB-DTPA were 20,824 (62%), 10,417 (31%) and 2,359 (7%), respectively. Total 39 adverse reactions were reported accounting for 0.1161% of all administrations. The incidences of adverse reactions were 0.1248% (26/39, 67%) for Gd-BT-DO3A, 0.0768% (8/39, 21%) for Gd-DTPA, and 0.2120% (5/39, 13%) for Gd-EOB-DTPA. The difference of frequencies of adverse reaction among three contrast agents was not significant. Most cases of the adverse effect were mild (35/39, 89.7%). Moderate and severe adverse reactions were encountered in two patients, respectively.
CONCLUSION
Among Koreans, adverse effects were rare, and especially, moderate to severe adverse reactions were much rarer. There was no difference among the frequencies of adverse reactions caused by three different contrast agents.

Keyword

Magnetic resonance imaging (MRI); Contrast agents; Adverse reaction; Reporting system

MeSH Terms

Accounting
Administration, Intravenous
Contrast Media
Electronics
Electrons
Gadolinium DTPA
Hospital Information Systems
Humans
Incidence
Retrospective Studies
Contrast Media
Gadolinium DTPA

Figure

  • Fig. 1 Distributions of severity of adverse reactions by contrast agents. (a) Overall distribution of severity of adverse reactions by all three contrast agents. (b) Distribution of severity of adverse reactions by Gd-BT-DO3A. (c) Distribution of severity of adverse reactions by Gd-DTPA. (d) Distribution of severity of adverse reactions by Gd-EOB-DTPA.


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