J Korean Fract Soc.  2002 Apr;15(2):271-277. 10.12671/jksf.2002.15.2.271.

Effect of injected calcium-sulfate on the consolidation of distraction osteogenesis in rabbit model

• Oh CW
• Kim PT
• Park BC
• Park IH
• Kyung HS
• Baek SH

• KMID: 1999409
• DOI: http://doi.org/10.12671/jksf.2002.15.2.271

Abstract

PURPOSE: To investigate whether injection of calcium sulfate salt powder could be used to facilitate consolidation of early & fast distraction osteogenesis.
MATERIALS AND METHODS
Group I was experimental group and Groups II and III were controls. After 3 days of latency period, a small distractor was distracted for a total of 8 mm for 4 days. Calcium sulfate salt powder suspended in carboxymethylcellulose(CMC) solution was injected, whereas CMC media alone was injected in one control group and without intervention in the other control group. Plain radiographs were taken on every weeks. We assesed the bone mineral density(BMD) at 3 and 6 weeks and %BMD was calculated. The rabbits were sacrificed at 6 weeks for histologic examination.
RESULTS
In radiography, the distracted area was consolidated in the experimental group but not in control groups. The % BMD of the experimental group was significantly greater than that of control groups at 6 weeks(p<0.01). In histologic examination, greater amount of newly formed bone was noted in the distraction zone of the experimental group, compared to two control groups.
CONCLUSION
Implantation of calcium sulfate powder can accelerate consolidation in distraction osteogenesis in rabbits.

Keyword

rabbit tibia model; early & fast distraction osteogenesis; injected calcium-sulfate powder; consolidation

MeSH Terms

Calcium Sulfate
Equidae
Latency Period (Psychology)
Osteogenesis, Distraction*
Rabbits
Radiography
Calcium Sulfate