Obstet Gynecol Sci.  2015 Jan;58(1):40-45. 10.5468/ogs.2015.58.1.40.

Type-specific persistence or regression of human papillomavirus genotypes in women with cervical intraepithelial neoplasia 1: A prospective cohort study

Affiliations
  • 1Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea. jhhong93@korea.ac.kr

Abstract


OBJECTIVE
To evaluate the type-specific human papillomavirus (HPV) persistence or regression in women with or less than low-grade cervical intraepithelial neoplasia (CIN).
METHODS
This prospective cohort study included patients with or less than cytological low-grade squamous intraepithelial lesion (or histologically CIN 1 when biopsy was performed) combined with HPV infection. The cohort was collected from July 2006 to November 2011 at Korea University Guro Hospital. Follow-up was performed with liquid-based Papanicolaou test, hybrid capture 2 test, AnyplexTM II HPV 28 Detection, colposcopic biopsy if necessary every 4 months. All patients were prospectively observed without treatment.
RESULTS
One hundred and thirty-seven patients were enrolled. Of these, 21 patients whose minimum follow-up periods were less than 8 months were excluded. Finally, one hundred sixteen patients were included and followed-up. Median follow-up period was 16 months. In case of high-risk HPVs, HPV 53 was the most prevalent type, followed by HPV 52, 68, 66, and 16. HPV 16 took 10.6 months to regress spontaneously, which was the longest period among the 10 most prevalent high-risk HPV genotypes. In case of spontaneous regression, HPV clearance was always accompanied by lesion clearance. A total of 13 patients showed disease progression either cytologically or histologically. Two cases of CIN 3 were confirmed by colposcopy-directed biopsy during follow-up, which were subsequently managed by conization.
CONCLUSION
HPV 16 is the most persistent HPV genotypes. Studies with longer term follow-up and larger sample size are needed to demonstrate whether persistence of HPV 16 is directly correlated with progression of low-grade lesions.

Keyword

Cervical intraepithelial neoplasia; Genotype; Human papillomavirus

MeSH Terms

Biopsy
Cervical Intraepithelial Neoplasia*
Cohort Studies*
Conization
Disease Progression
Female
Follow-Up Studies
Genotype*
Human papillomavirus 16
Humans
Korea
Papanicolaou Test
Prospective Studies*
Sample Size

Figure

  • Fig. 1 Type-specific prevalence of human papillomavirus (HPV) genotypes at enrollment.

  • Fig. 2 Mean time to regression of the 10 most prevalent high-risk human papillomavirus (HPV) genotypes.


Cited by  1 articles

Risk factors for cytological progression in HPV 16 infected women with ASC-US or LSIL: The Korean HPV cohort
Kyeong A So, Seon Ah Kim, Yoo Kyung Lee, In Ho Lee, Ki Heon Lee, Jee Eun Rhee, Mee Kyung Kee, Chi Heum Cho, Sung Ran Hong, Chang Sun Hwang, Mi Seon Jeong, Ki Tae Kim, Moran Ki, Soo Young Hur, Jong Sup Park, Tae Jin Kim
Obstet Gynecol Sci. 2018;61(6):662-668.    doi: 10.5468/ogs.2018.61.6.662.


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