Korean J Obstet Gynecol.  2004 Mar;47(3):451-457.

Effect of Surgical Therapy on the Courses of Human Papillomavirus Infection in Cervical Intraepithelial Neoplasia

• Roh JL
• Kim JW
• Kim YT
• Kim SH
• Kim KH

Abstract

OBJECTIVE
To investigate whether human papillomavirus (HPV) associated with cervical intraepithelial neoplasia was successfully eliminated after surgical therapy such as large loop excision of transformation zone (LLETZ) or type I extended hysterectomy.
METHODS
Seventy four cervical intraepithelial neoplasia (CIN) patients with HPV infection who were admitted for LLETZ or type I extended hysterectomy were recruited into this prospective study. HPV infection was confirmed by HPV DNA genotyping using HPV DNA Chip (Biomedlab, Seoul, Korea) before and after surgical therapy.
RESULTS
According to the assay used (HPV DNA Chip(R)) at the postoperative visit, 82.5% of treated patients were completely free from HPV infection. And there was no statistical difference between LLETZ and type I extended hysterectomy (p=0.452). However, there was persistent infection in 17.5% of treated patients after final surgical therapy.
CONCLUSION
Although the HPV infection associated with CIN was effectively eliminated after LLETZ and type I extended hysterectomy, there was persistent infection in 17.5% of treated patients. Therefore, the careful followed-up examination of HPV infection should be taken in these patients.

Keyword

Human papillomavirus (HPV); Cervical intraepithelial neoplasia (CIN); HPV DNA genotyping; Surgical therapy

MeSH Terms

Cervical Intraepithelial Neoplasia*
DNA
Humans*
Hysterectomy
Oligonucleotide Array Sequence Analysis
Papillomavirus Infections*
Prospective Studies
Seoul
DNA