Renal Prostaglandins and Calcium Excretion in Urolithiasis

Choi, Kyung Soo; Choi, Han Yong

Abstract

It is suggested that renal prostaglandins influence intrarenal hemodynamics and tubular electrolyte excretions, so participate in calcium stone formation by regulating the renal tubular handling of calcium. To investigate the pathogenic role of renal prostaglandin in hypercalciuria, we assessed urinary excretion of sodium and calcium in 21 patients with idiopathic urolithiasis(13 normocalciuric and 8 hypercalciuric patients) and determined the change in calcium and sodium excretion following prostaglandin syntetase inhibition with indomethacin. The results obtained were summarized as follows: 1. In 13 normocalciuric patients, 24-hour urine calcium excretion was 154+/-63.8 mg/day (mean+/-S.D.) and in 8 hypercalciuric patients, 440+/-82.1 mg/day. 2. The urinary sodium excretion in the hypercalciuric group(172.6+/-32.6 mEq/day) was significantly higher than that in the normocalciuric group(123.5+/-44.4 mEq/day) (p<0.05). 3. In the hypercalciuric group, calcium excretion was significantly reduced by indomethacin (p<0.05). Sodium excretion was also reduced by indomethacin but there was no significance. 4. In the normocalciuric group, there was no significant change of sodium and calcium excretion after administration of indomethacin.