Biochemical Study of Urolithiasis

Kim, Kyung Do; Kim, Young Kyoon

Abstract

A study was made on 40 cases of urolithiasis and 40 cases of control group to show the relationship between stone formation and urinary excretion and serum level of calcium and phosphorus. This study was also made to show the relationship between urinary excretion of calcium and phosphorus and the chemical composition of stones. Followings were the results: 1. The urinary excretion of calcium per day is higher in the lithiasis group than in the control group. Control group : 126.3+/-63.5mg/day Lithiasis group : 182.5+/-73.5mg/day 2. The urinary excretion of phosphorus per day is not significantly different between the lithiasis group and the control group. Control group : 588+/-223mg/day Lithiasis group : 548+/-178mg/day 3. The variance of urinary calcium concentration is not significantly different between the lithiasis group and the control group. Control group : 72.3+/-44.9 micro gm/ml Lithiasis group : 84.5+/-45.8 micro gm/ml 4. The incidence of high urine-calcium values (>180mg/day) is greater in the lithiasis group (50%) than in the control group (22.5%). 5. The incidence of high urine-calcium values(>180mg/day) decreases in the following order : mixed calcium oxalate-calcium phosphate stone (63.6%), calcium oxalate stone (33.3%), calcium phosphate stones (33.3%), control group (22.5%), other types of stone (0%). 6. 87.5% of stone patients had normal serum-calcium values (8.6-11.0mg%) and one patient (2.5%) had higher level than the normal. The results suggest that the urinary excretion of calcium per day is an important factor in stone formation and it appears to influence the types of stone formed.