Korean J Nucl Med.  2004 Dec;38(6):528-531.

Evaluation of Cat Brain Infarction Model Using MicroPET

Affiliations
  • 1Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.dsl@plaza.snu.ac.kr
  • 2Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.

Abstract

PURPOSE
PET has some disadvantage in the imaging of small animal due to poor resolution. With the advent of microPET scanner, it is possible to image small animals. However, the image quality was not good enough as human image. Due to larger brain, cat brain imaging was superior to mouse or rat. In this study, we established the cat brain infarction model and evaluate it and its temporal change using microPET scanner. MATERIALS AND METHODS: Two adult male cats were used. Anesthesia was done with xylazine and ketamine HCl. A burr hole was made at 1cm right lateral to the bregma. Collagenase type IV 10 microliter was injected using 30 G needle for 5 minutes to establish the infarction model. 18F-FDG microPET (Concorde Microsystems Inc., Knoxville, TN) scans were performed 1, 11 and 32 days after the infarction. In addition, 18F-FDG PET scans were performed using human PET scanner (Gemini, Philips medical systems, CA, USA) 13 and 47 days after the infarction. RESULTS: Two cat brain infarction models were established. The glucose metabolism of an infarction lesion improved with time. An infarction lesion was also distinguishable in the human PET scan. CONCLUSION: We successfully established the cat brain infarction model and evaluated the infarcted lesion and its temporal change using 18F-FDG microPET scanner.

Keyword

Cat; brain infarction; microPET

MeSH Terms

Adult
Anesthesia
Animals
Brain Infarction*
Brain*
Cats*
Collagenases
Fluorodeoxyglucose F18
Glucose
Humans
Infarction
Ketamine
Male
Metabolism
Mice
Needles
Neuroimaging
Positron-Emission Tomography
Rats
Xylazine
Collagenases
Fluorodeoxyglucose F18
Glucose
Ketamine
Xylazine
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