Korean J Nephrol.  2000 Nov;19(6):1071-1077.

Relationship Between Serum Magnesium and Parathyroid Hormone Levels in Hemodialysis Patients

• Ma SK
• Kim JK
• Park MJ
• Park BS
• Nah MY
• Yeum CH
• Kim SW
• Kim NH
• Kang YJ
• Choi KC

Abstract

The important factors involved in the regulation of PTH are calcium, vitamin D, and phosphorus. However, recent studies have suggested that magnesium may also play a significant role in the modulation of PTH. The aims of this study was to analyze the relationship between serum magnesium and PTH levels in the hemodialysis patients. We studied 66 stable patients under maintenance hemodialysis for more than 6 months. Calcium carbonate was used as a phosphate binder in all patients. No patient had been previously treated with vitamin D and aluminum hydroxide. Biochemical parameters were evaluated 3 times during 7 months, and the mean values were computed. The mean serum magnesium level was 2.7+/-0.4 mEq/L. Hypermagnesemia(defined as serum Mg>2.2 mEq/L) was found in 60 patients(90.1%). Serum magnesium levels were inversely correlated with serum iPTH levels(r=-0.579; p<0.001). Serum total and ionized calcium levels were inversely correlated with serum iPTH levels(r=-0.743; p<0.001, r=-0.699; p<0.001, respectively). Serum alkaline phosphatase levels positively correlated with serum iPTH levels (r=0.364; p=0.003). In lower iPTH group(serum iPTH

Keyword

Magnesium; Parathyroid hormone (PTH); Renal osteodystrophy; Calcium sensing receptor

MeSH Terms

Alkaline Phosphatase
Aluminum Hydroxide
Calcium
Calcium Carbonate
Humans
Magnesium*
Parathyroid Hormone*
Phosphorus
Receptors, Calcium-Sensing
Renal Dialysis*
Renal Osteodystrophy
Vitamin D
Alkaline Phosphatase
Aluminum Hydroxide
Calcium
Calcium Carbonate
Magnesium
Parathyroid Hormone
Phosphorus
Receptors, Calcium-Sensing
Vitamin D