Korean J Med.  2002 Nov;63(5):496-506.

Clinical features of bronchogenic large cell carcinoma confirmed by surgical resection

• Park MS
• Shin DH
• Chung KY
• Cheong JH
• Chung JH
• Kim DH
• Kim SK
• Chang J
• Kim JH
• Kim SK
• Kim YS

Abstract

BACKGROUND: To define the final outcome of large cell carcinoma (LCC) after surgical treatment, we reviewed the histopathology, clinical features and follow-up results of 28 cases.
METHODS
We retrospectively reviewed 28 patients with LCC who underwent surgical resection during the last 15 years from 1986 to 2001 in Severance Hospital. We evaluated clinical data, radiologic findings, pathologic findings, treatment modalities, and survival.
RESULTS
The prevalence of LCC was 2.9% (29 cases) among the surgically resected cases in primary lung cancer (1003 cases) during 15 years. The mean age was 59 years old and twenty five cases were male. There were 23 smokers and the average pack year was 33. The cough was the most frequent symptom. Fifteen cases were located in the peripheral part of the lung. Twenty cases consisted of lobulated mass. In chest CT scan, twenty six cases had necrotic portions which appeared to be lower density. Postoperative stage was IA in 1 case (3.6%), IB in 11 cases (39.3%), IIB in 8 cases (28.5%), IIIA in 7 cases (25%), and IV in 1 case (3.6%). Preoperative and postoperative stage concordance rate was 43%. Median survival time was 54.5 months and 5 year-survival rate was 45%.
CONCLUSION
Our results suggest that LCC in the lung is predominant in male and is equally located in the central and peripheral parts of the surgically resected cases. To define the treatment outcome and risk factors of LCC of the lung, further multicenter studies are needed.

Keyword

Carcinoma; Large cell; Diagnosis; Treatment outcome

MeSH Terms

Carcinoma, Large Cell*
Cough
Diagnosis
Follow-Up Studies
Humans
Lung
Lung Neoplasms
Male
Middle Aged
Prevalence
Retrospective Studies
Risk Factors
Tomography, X-Ray Computed
Treatment Outcome