Korean J Perinatol.  2009 Mar;20(1):65-68.

A case of hemolytic disease of the newborn caused by anti-c and anti-E antibody requiring multiple exchange transfusions

• Lee HH
• Kim TY
• Park MJ
• Sung TJ

Abstract

ABO and Rh (D) incompatibility have been the most common hemolytic disease of newborn, but recently because of Rh (D) immune globulin prophylaxis, the incidence of Rh (D) incompatibility has decreased while the incidence of hemolytic disease of newborn due to minor blood group incompatibility seems to be increased. A 2-days old female neonate was admitted at our hospital because of severe progressive jaundice and anemia, which were developed within the several hours after birth. Laboratory results showed typical hemolytic anemia but there were no evidence of incompatibility of ABO and Rh (D) system between baby and mother. The newborn's indirect and direct antiglobulin tests were positive. Minor blood group was tested and high titer of anti-c and anti-E were detected both in mother's and baby's serum. She was treated with three times exchange transfusion and intensive phototherapy. Then she was discharged on 9th hospital day with good condition. We report the case with a brief review of relevant literatures.

Keyword

Hyperbilirubinemia; Isoimmune Hemolytic anemia; Minor blood group incompatibility

MeSH Terms

Anemia
Anemia, Hemolytic
Blood Group Incompatibility
Coombs Test
Erythroblastosis, Fetal
Female
Humans
Hyperbilirubinemia
Incidence
Infant, Newborn
Jaundice
Mothers
Parturition
Phototherapy