Korean J Pediatr.  2005 Mar;48(3):292-297.

Clinical Characteristics of Autoimmune Thyroid Disease Developed in Patients with Type 1 Diabetes Mellitus

• Lee SM
• Chung HR
• Hong SY
• Shin CH
• Yang SW

Abstract

PURPOSE
It is known that 3-50 percent of type 1 diabetes mellitus(T1DM) patients develop autoimmune thyroid disease. We analyzed the clinical characteristics of autoimmune thyroid disease(AITD) developed in patients with T1DM in Korean.
METHODS
The medical records of 139 patients, who were followed up in Department of Pediatrics, Seoul National University Children's Hospital from Jan. 1981 to Jul. 2004, were analyzed retrospectively.
RESULTS
Forty-four males and 95 females were enrolled. At least one of the autoantibodies for thyroid was positive in 54 cases. The detection rate for AITD was not correlated with sex ratio, control of T1DM, body mass index, age at diagnosis of T1DM, and familial history of thyroid disease, between two groups. In the male group, AITD was more frequently found at a younger age than in the female group. The frequency of AITD was significantly higher in the goiter group without sex differences. In the thyroid disease group, 40 patients(74.0 percent) were euthyroid, seven patients(12.9 percent) were hypothyroid, and seven patients(12.9 percent) were hyperthyroid.
CONCLUSION
We should monitor thyroid function and autoantibodies routinely in T1DM patients who develop goiters, or young boys with T1DM.

Keyword

Type 1 diabetes mellitus(T1DM); Autoimmune thyroid disease(AITD)

MeSH Terms

Autoantibodies
Body Mass Index
Diabetes Mellitus, Type 1*
Diagnosis
Female
Goiter
Humans
Male
Medical Records
Pediatrics
Retrospective Studies
Seoul
Sex Characteristics
Sex Ratio
Thyroid Diseases*
Thyroid Gland*
Autoantibodies